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Saturday, May 16, 2020 | History

2 edition of Regulation of glycogen synthase kinase-3. found in the catalog.

Regulation of glycogen synthase kinase-3.

Vuk Stambolic

Regulation of glycogen synthase kinase-3.

by Vuk Stambolic

  • 55 Want to read
  • 33 Currently reading

Published .
Written in English


The Physical Object
Pagination174 leaves.
Number of Pages174
ID Numbers
Open LibraryOL18523571M
ISBN 100612277305

  Glycogen is the storage form of carbohydrates in mammals. In humans the majority of glycogen is stored in skeletal muscles (∼ g) and the liver (∼ g). Food is supplied in larger meals, but the blood glucose concentration has to be kept within narrow limits to survive and stay healthy. Therefore, the body has to cope with periods of excess carbohydrates and periods without Cited by: Glycogen synthase kinase-3 (GSK-3)-α and -β are closely related protein-serine kinases, which act as inhibitory components of Wnt signalling during embryonic development and cell proliferation.

Effects of a fructose-rich diet and chronic stress on insulin signaling and regulation of glycogen synthase kinase-3 beta and the sodium–potassium pump in the hearts of male rats S. Romic, A. Djordjevic, S. Tepavcevic, T. Culafic, M. Stojiljkovic, B. Bursac, J. Stanisic, M. Kostic, L. Gligorovska and G. Koricanac, Food Funct., , 11, Author: Snjezana Romic, Ana Djordjevic, Snezana Tepavcevic, Tijana Culafic, Mojca Stojiljkovic, Biljana Burs. Glycogen synthase kinase 3 (GSK3) was initially discovered as a kinase involved in the regulation of glucose metabolism and later as a participant in wnt/wingless signaling. In mammals, two closely related isoforms GSK3α and GSK3β are present (Woodgett ). The GSK3β isoform is highly expressed in neural tissue where its expression is Cited by:

Glycogen Synthase Kinase 3 Ana Martinez, Ana Castro, Miguel Medina, Binghe Wang Many researchers believe that GSK-3 and its inhibitors could lead to effective treatments for neurogenerative disorders, type II diabetes, depression and bipolar disorder, and some forms of cancer. Bottom Line: In humans the majority of glycogen is stored in skeletal muscles (∼ g) and the liver (∼ g).The glycogen stores in skeletal muscles are limited because an efficient feedback-mediated inhibition of glycogen synthase prevents reduction of skeletal muscle glycogen after exercise allows a healthy storage of carbohydrates after meals and prevents development.


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Regulation of glycogen synthase kinase-3 by Vuk Stambolic Download PDF EPUB FB2

Glycogen Synthase Kinase 3. Glycogen synthase kinase 3 (GSK-3) is an enzyme which was first discovered based on its ability to phosphorylate and inactivate the enzyme glycogen synthase, an action that leads to a decrease in the synthesis of glycogen.

From: Companion to Psychiatric Studies (Eighth Edition), Related terms. Introduction. Glycogen synthase kinase 3 (GSK3) was identified over 20 years ago as a protein kinase that phosphorylated and inhibited glycogen synthase, the enzyme that catalyzes the transfer of glucose from UDPG to uently, two separate isoforms were cloned, termed GSK3α and enzymes have extremely similar catalytic domains, the major distinguishing feature being Cited by: 2.

Regulation of Akt and glycogen synthase kinase-3 beta phosphorylation by sodium valproate and lithium. De Sarno P(1), Li X, Jope RS. Author information: (1)Department of Psychiatry and Behavioral Neurobiology, Sparks CenterUniversity of Alabama at Cited by: Glycogen synthase kinase 3 beta, also known as GSK3B, is an enzyme that in humans is encoded by the GSK3B gene.

In mice, the enzyme is encoded by the GSK-3β gene. Abnormal regulation and expression of GSK3β is associated with an increased susceptibility towards bipolar s: GSK3B, Gsk3b, F15Rik. The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf.

Biochem J. ; – by:   Glycogen synthase kinase 3 (GSK-3) is involved in the regulation of several physiological processes, including glycogen metabolism, protein synthesis, transcription factor activity, and developmental control.

Although GSK-3–like genes have been isolated from plants, no function for any of these kinases has been defined. We report here that the alfalfa wound-induced gene (WIG, for Cited by: Not long ago, glycogen synthase kinase-3 (GSK3) se emed to be a rather curious enzyme in a number of wa ys, but perhaps not one of especially widesp read importance (Gr imes & Jope, ; Wood gett.

In addition, protein kinase B is activated, which reinforces the phosphorylation of glycogen synthase kinase 3 (GSK3) and thereby inactivates it. As a result, GSK3 phosphorylates the glycogen synthase to a lesser extent, causing the latter to become.

Glycogen synthase kinase 3: A key regulator of cellular fate Article Literature Review (PDF Available) in Cellular and Molecular Life Sciences CMLS 64(15) September with Reads.

Regulation by Glycogen Synthase Kinase-3β of the Arborization Field and Maturation of Retinotectal Projection in Zebrafish Hirofumi Tokuoka, Tomoyuki Yoshida, Naoto Matsuda, Masayoshi Mishina Journal of Neuroscience 1 December22 (23) ; DOI: /JNEUROSCICited by: Abstract.

Glycogen synthase, the regulatory enzyme of glycogen synthesis undergoes multisite phosphorylation leading to its inactivation. The kinases responsible for this covalent modification (ex.

cAMP-dependent protein kinase, protein kinase C and glycogen synthase kinase-3) are controlled by the second messengers generated by different by: Abstract.

There are two homologous forms of glycogen synthase kinase (GSK)-3, GSK-3α and GSK-3β, which play overlapping roles in the regulation of Wnt, Hedgehog, and insulin pathways, as well as the activation of nuclear factor (NF)-kB-mediated gene by: Title:Inhibition of Glycogen Synthase Kinase-3 Reverses Tau Hyperphosphorylation Induced by Pin1 Down-Regulation VOLUME: 12 ISSUE: 3 Author(s):Yan-Si Xiong, Dan-Li Wang, Lu Tan, Xiong Wang, Li-Ming Chen, Cheng-Xin Gong, Jian-Zhi Wang and Ling-Qiang Zhu Affiliation:(Ling-Qiang Zhu) Department of Pathophysiology, Key Laboratory of Neurological Diseases of Education Committee of China, Tongji.

Glycogen synthase kinase-3 β (GSK-3 β) is known to affect a diverse range of biological functions controlling gene expression, cellular architecture, and apoptosis.

GSK-3 β has recently been identified as one of the important pathogenic mechanisms in motor neuronal death related to Cited by: 4.

Specific involvement of glycogen synthase kinase-3 in the function and activity of sex steroid hormone receptors reveals the complexity of their regulation. The Journal of Steroid Biochemistry and Molecular Biology(), Cited by: : TOR and GSK3 in the ciliate Paramecium tetraurelia: Target of Rapamycin and Glycogen Synthase Kinase 3 pathway orthologs and their regulation of ciliary length/assembly (): Tatyana Svinkina: BooksAuthor: Tatyana Svinkina.

Abstract. Glycogen synthase kinase-3 is a Ser/Thr kinase, tonically active in resting cells but inhibited by phosphorylation of an N-terminal Ser residue (Ser 21 in GSK3α and Ser 9 in GSK3β) in response to varied external stimuli.

Recent work suggests that GSK3 functions as a negative regulator of platelet function, but how GSK3 is regulated in platelets has not been examined in detail.

THE JOURNAL OF BIOLOGICAL CHEMISTRY 0 by The American Society for Biochemistry and Molecular Biology, Inc. Vol.No. 24, Issue of Aug pp. Printed in U. S.A. Differential Regulation of Glycogen Synthase Kinase-3P by Protein Kinase C Isotypes* (Received for publication, ) Nigel Goode$, Kenneth Hughes§, James R.

WoodgettQ, and Peter J. Glycogen synthase kinase-3 has previously been implicated in regulating pro-survival NF-κB signaling in pancreatic cancer cells through an unknown mechanism. Moreover, TGF-β activated kinase 1 (TAK1) is a known regulator of NF-κB activity in human cancers, but its Cited by: 2.

Title:Regulation of Skeletal Muscle Plasticity by Glycogen Synthase Kinase-3β: A Potential Target for the Treatment of Muscle Wasting VOLUME: 19 ISSUE: 18 Author(s):Koen J.P.

Verhees, Nicholas A.M. Pansters, Annemie M.W.J. Schols and Ramon C.J. Langen Affiliation:Department of Respiratory Medicine, PO boxAZ Maastricht. Glycogen Synthase Kinase-3 (GSK-3) is a critical downstream regulator in multiple signaling pathways including neurotrophin/PI3K and Wnt/[beta]-catenin pathways.

GSK-3 signal has been strongly implicated in the regulation of neuronal polarity and axon growth in : Xinshuo Wang.7 Glycogen Synthase Kinase 3: A Target for Novel Mood Disorder Treatments 8 GSK-3 and Stem Cells 9 Glycogen Synthase Kinase 3: Role in Neurodegeneration and Neuroprotection 10 Protein Kinase Assays for Drug Discovery 11 Animal Models with Modifi ed Expression of GSK-3 for the Study of Its Physiology and of Its Implications.Control of Glycogen Metabolism Glycogen synthase bicyclic cascade Not as well understood Two forms of enzyme: m-glycogen synthase b (inactive) allosterically controlled - inhibited by ATP, ADP, Pi overcome by [glucosephosphate] > 10 mM (rare) o-glycogen synthase a (active) deactivated by calmodulin-dependent protein kinase,File Size: 96KB.